Sunifiram – DM235 supports memory and nervous system health.
Like many nootropics, this drug is being developed and studied as a potential treatment for various degenerative diseases such as Alzheimer’s, Parkinson’s, and dementia. Sunifiram also shows promise in treating attention problems. A derivative of racetam, research suggests it is as much as 1,000 times more potent than phenylpiracetam and 30,000 times more potent than piracetam and at a fraction of its price. This translates to an extremely low cost per dose, which is ideal for people on a tight budget (e.g., students always complaining about the lack of money).
The exact mechanisms involved in the action of Sunifiram remain unknown. However, some preliminary research suggests that it probably works on many different targets in our body and brain Unifiram and Sunifiram Nootropics – Research Analysis (PubMed)
Some of the possible mechanisms that have been proposed so far include:
1. May Stimulate Acetylcholine Release: According to several early studies in mice, Sunifiram counteracted the effects of scopolamine, a drug known to block the release of the neurotransmitter acetylcholine. These findings have led some researchers to suggest that one of sunifiram’s main effects may be to increase acetylcholine activity throughout the brain. Piperazine Nootropic DM‑232 (Unifiram) – Structural Studies (PubMed)
2. May Block AMPA Receptors: Similarly, another mouse study found that Sunifiram counteracted the effects of other experimental drugs believed to inhibit the activity of AMPA receptors, which play a major role in stimulating synaptic plasticity. AMPA Receptor Activation – Unifiram and Sunifiram Against Amnesia (PubMed)
3. Can activate NMDA glutamate receptors: According to two studies in cells and live mice, Sunifiram can also promote the release of the excitatory neurotransmitter glutamate. This, in turn, may increase the activity of NMDA receptors to which glutamate binds to stimulate synaptic plasticity. Sunifiram – Enhancement of Synaptic Plasticity in the Hippocampus (PubMed)
4. May Affect Cellular Energy Use: The brain relies heavily on glucose to help fuel cells, which is delivered to neurons by red blood cells. According to one cell study, Sunifiram was supposed to counteract the inhibition of glucose transport across cell membranes caused by another drug called phenobarbital. This may suggest that some of Sunifiram’s potential effects may be due to its ability to influence how cells receive and use energy. However, this effect can be complex: for example, the authors of this study reported that Sunifiram may increase glucose uptake at lower doses but decrease it at higher doses. Piracetam and TRH – Mitigation of Barbiturate-Induced Inhibition of Glucose Transport
Personally, I love it, one of my faves ‘’go to’’ nootropic powders when really sharp and augmented concentration is needed . The more complex materials to learn, the faster the assimilation of them. People who have been to my seminars on brain chemistry should know this compound by heart now and should know its well worth having around when the time comes. Works well with other nootropics, the like of Alpha GPC, caffeine, theanine, phenethylamine (PEA) and hordenine. Dosage 5-10mg is more then enough.
